Accelerating innovation in viral vector processing
Develop, optimise and scale-up your viral vector project with our Biotherapeutics capabilities
We are a leading independent technology innovation centre and a founding member of the UK Government’s High Value Manufacturing Catapult. Established in 2004, our teams tirelessly apply their many years of experience to ensure that every great invention gets the best opportunity to become a successfully marketed product or process.
We help companies to develop, prove, and scale-up the next generation of biologic products and processes and provide our partners with access to the following capabilities:
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Access to bioprocess development and scale-up experts.
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End-to-end workflow, from small scale to large scale manufacturing.
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Experience with a range of AAV serotypes and lentiviral vectors.
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Access to a diverse range of equipment and expertise.
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Tech transfer to a client’s manufacturing facility or CMO.
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Expertise in formulation, cryopreservation development, forced degradation and stability studies.
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Experience in helping clients to reduce batch-batch variability and improve product quality and quantity.
Our track record of innovation
We have worked on a number of viral vector projects with multiple partners from SMEs to large corporates.
Cobra Biologics
Development of an industrial manufacturing platform for adeno-associated virus (AAV) productionInnovation Insights
Read what our experts have to say on viral vectors.
Viral vectors for gene therapy
Revolutionising medicine by supporting process development for AAV viral vectors.Industry challenges
We know current methods of viral vector manufacture are highly inefficient which is putting a strain on drug developers and manufacturers alike.
- Upstream titer is low and inconsistent
- Poor scalability for adherent processes: 2D for process development to 3D for production
- Difficulties in process adaption from adherent to suspension
- Downstream recovery is low
- Analysis of yield and quality is hampered by limited analytical methods
- High cost of goods
Additionally, when we consider the manufacturing inefficiencies associated with viral vector manufacture such as spoilage, batch failures and QC sampling, organisations are needing to produce on average double the amount they need to accommodate the losses which is time consuming and costly.
Our viral vector capabilities
CPI can help you accelerate viral vector development towards in-human trials and enhance product manufacturability by improving process yield and reducing process variability by generating a robust, scalable and fully transferable process.
Accelerate process development.
Improve process yield.
Reduce process variability.
Produce transferable processes.
Improve process economics and scalability.
Consultancy.
A collaborative approach
CPI works closely with the Cell and Gene Therapy Catapult who bring a breadth of knowledge and experience in the area of viral vector processing. They offer:
- Access to 200+ cell and gene therapy experts
- MHRA-licensed GMP manufacturing facility
- Commercial readiness expert support
- Advanced Therapy Treatment Centre Network